製品の概要

  • 製品名Anti-Importin 13 antibody
    Importin 13 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Importin 13
  • アプリケーション適用あり: WB, IP, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide containing a sequence corresponding to a region within amino acids 901-963 (SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL CRGLHGTDYT ADY) of Human Importin 13 (NP_055467).

  • ポジティブ・コントロール
    • HeLa whole cell lysate; HeLa cells

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab95993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 108 kDa.
IP Use at 10-1 µg/mg of lysate.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
  • 組織特異性Expressed in fetal brain, heart, intestine and kidney.
  • 配列類似性Belongs to the importin beta family.
    Contains 14 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Imp 13 antibody
    • Imp13 antibody
    • Importin-13 antibody
    • Importin13 antibody
    • IPO 13 antibody
    • Ipo13 antibody
    • IPO13_HUMAN antibody
    • Kap 13 antibody
    • Kap13 antibody
    • Karyopherin 13 antibody
    • Karyopherin-13 antibody
    • Karyopherin13 antibody
    • KIAA0274 antibody
    • Late gestation lung 2 antibody
    • Late gestation lung 2 protein antibody
    • Lgl2 antibody
    • Ran binding protein 13 antibody
    • Ran-binding protein 13 antibody
    • RanBP 13 antibody
    • RanBP13 antibody
    see all

Anti-Importin 13 antibody 画像

  • Importin 13 was immunoprecipitated from 1 mg of HeLa whole cell lysate using 10 µg of ab95993. The precipitated Importin 13 was detected with ab95993 at 1/1000 dilution.
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab95993 at 1/200 dilution. Lower image is merged with DNA probe.

Anti-Importin 13 antibody (ab95993) 使用論文

ab95993 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95993.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"