Anti-IL7R alpha (phospho Y449) 抗体 (ab73341)


  • 製品名Anti-IL7R alpha (phospho Y449) antibody
    IL7R alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IL7R alpha (phospho Y449)
  • 特異性ab73341 detects endogenous levels of IL7R alpha only when phosphorylated at tyrosine 449.
  • アプリケーション適用あり: WB, ELISA, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human IL7R alpha around the phosphorylation site of tyrosine 449 (EAYPVT)

  • ポジティブ・コントロール
    • HeLa cell extract. HUVEC cells.




Our Abpromise guarantee covers the use of ab73341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 52 kDa).
ELISA 1/5000.
ICC/IF 1/500 - 1/1000.


  • 機能Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
  • 関連疾患Defects in IL7R are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
    Genetic variations in IL7R are a cause of susceptibility to multiple sclerosis type 3 (MS3) [MIM:612595]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.
  • 配列類似性Belongs to the type I cytokine receptor family. Type 4 subfamily.
    Contains 1 fibronectin type-III domain.
  • ドメインThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 翻訳後修飾N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 127 antibody
    • CD127 antibody
    • CD127 antigen antibody
    • CDw127 antibody
    • IL 7R alpha antibody
    • IL 7R antibody
    • IL-7 receptor subunit alpha antibody
    • IL-7R subunit alpha antibody
    • IL-7R-alpha antibody
    • IL-7RA antibody
    • IL7R antibody
    • IL7RA antibody
    • IL7RA_HUMAN antibody
    • IL7Ralpha antibody
    • ILRA antibody
    • Interleukin 7 receptor alpha chain antibody
    • Interleukin 7 receptor antibody
    • Interleukin 7 receptor isoform H5 6 antibody
    • Interleukin-7 receptor subunit alpha antibody
    see all

Anti-IL7R alpha (phospho Y449) antibody 画像

  • All lanes : Anti-IL7R alpha (phospho Y449) antibody (ab73341) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HeLa cell extract with immunising phosphopeptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 52 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • Immunofluorescence analysis of IL7R alpha in HUVEC cells using ab73341 at 1/500 dilution in the presence (right panel) or absence (left panel) of immunising phosphopeptide.

Anti-IL7R alpha (phospho Y449) antibody (ab73341) 使用論文

ab73341 has not yet been referenced specifically in any publications.

Product Wall

The most recent email I sent provided you the credit ID number and directions on how to use the credit ID number to receive the refund you requested.

If this is not the resolution you had intended, please let me know how I can help.

I am sorry that this antibody did not perform as stated on the datasheet. If payment has already been made on the original order and you wish to receive a refund, please ask your purchasing department to contact our accounting department so ...

Read More