Anti-IL6 抗体 (Biotin) (ab84251)

製品の概要

  • 製品名
    Anti-IL6 antibody (Biotin)
    IL6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IL6 (Biotin)
  • 標識
    Biotin
  • アプリケーション
    適用あり: WB, ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length IL6 protein (Human) highly pure (>98%).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84251 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 24 kDa.
ELISA Use a concentration of 0.25 - 1 µg/ml. Can be paired for ELISA with Mouse monoclonal to IL6 (ab9324). To detect hIL-6 by direct ELISA (using 100 µl/well antibody solution) a concentration of 0.25 – 1.0 µg/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 – 0.4 ng/well of recombinant hIL-6.
Sandwich ELISA Use at an assay dependent dilution. To detect hIL-6 by sandwich ELISA (using 100 µl/well antibody solution) a concentration of 0.25 – 1.0 µg/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Mouse monoclonal to IL6 (ab9324) as a capture antibody, allows the detection of at least 0.2 – 0.4 ng/well of recombinant hIL-6.

ターゲット情報

  • 機能
    Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
  • 関連疾患
    Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
    Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
  • 配列類似性
    Belongs to the IL-6 superfamily.
  • 翻訳後修飾
    N- and O-glycosylated.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Interleukin BSF 2 antibody
    • B cell differentiation factor antibody
    • B cell stimulatory factor 2 antibody
    • B-cell stimulatory factor 2 antibody
    • BSF 2 antibody
    • BSF-2 antibody
    • BSF2 antibody
    • CDF antibody
    • CTL differentiation factor antibody
    • Hepatocyte stimulatory factor antibody
    • HGF antibody
    • HSF antibody
    • Hybridoma growth factor antibody
    • Hybridoma growth factor Interferon beta-2 antibody
    • IFN-beta-2 antibody
    • IFNB2 antibody
    • IL 6 antibody
    • IL-6 antibody
    • IL6 antibody
    • IL6_HUMAN antibody
    • Interferon beta 2 antibody
    • Interferon beta-2 antibody
    • Interleukin 6 antibody
    • Interleukin 6 (interferon beta 2) antibody
    • Interleukin BSF 2 antibody
    • Interleukin-6 antibody
    see all

参考文献

ab84251 has not yet been referenced specifically in any publications.

レビューと Q&A

The number of biotin molecules attached to each antibody molecule is on average 12. The attachment is via amine groups, for instance lysine side chains and N-terminal amines, and these are found on both chains, heavy and light.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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