Anti-IL23 Receptor 抗体 [RM0110-6D34] (ab86640)


  • 製品名Anti-IL23 Receptor antibody [RM0110-6D34]
    IL23 Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [RM0110-6D34] to IL23 Receptor
  • 特異性This antibody detects mouse IL23 Receptor in Western blotting.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Mouse recombinant protein of the extracellular domain of IL23 Receptor.



Our Abpromise guarantee covers the use of ab86640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 72 kDa.


  • 機能Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
  • 組織特異性Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
  • 関連疾患Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
    Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
  • 配列類似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 2 fibronectin type-III domains.
  • 翻訳後修飾Phosphorylated in response to IL23.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • IL 23R antibody
    • IL-23 receptor antibody
    • IL-23R antibody
    • Il23r antibody
    • IL23R_HUMAN antibody
    • Interleukin 23 receptor antibody
    • Interleukin-23 receptor antibody
    see all

Anti-IL23 Receptor antibody [RM0110-6D34] (ab86640) 使用論文

ab86640 has not yet been referenced specifically in any publications.

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