製品の概要

  • 製品名
    Anti-IL21 Receptor antibody [4A9] (Biotin)
    IL21 Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [4A9] to IL21 Receptor (Biotin)
  • 標識
    Biotin
  • アプリケーション
    適用あり: Flow Cytmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Rat YB2/0 hybridoma transfectant cell line expressing truncated IL21 Receptor

  • ポジティブ・コントロール
    • Mouse splenocytes, thymocytes or bone marrow cells

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, 150mM Sodium chloride, pH 7.2
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    モノクローナル
  • クローン名
    4A9
  • アイソタイプ
    IgG2a
  • 軽鎖の種類
    kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab95712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 0.25-0.5µg for 105-8 cells. in a final volume of 100 µL



ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能
    This is a receptor for interleukin-21.
  • 組織特異性
    Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
  • 配列類似性
    Belongs to the type I cytokine receptor family. Type 4 subfamily.
    Contains 2 fibronectin type-III domains.
  • ドメイン
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 翻訳後修飾
    C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD360 antibody
    • IL 21R antibody
    • IL-21 receptor antibody
    • IL-21R antibody
    • IL21 receptor antibody
    • IL21R antibody
    • IL21R_HUMAN antibody
    • Interleukin 21 receptor antibody
    • Interleukin-21 receptor antibody
    • MGC10967 antibody
    • NILR antibody
    • Novel interleukin receptor antibody
    see all

画像

  • Flow cytometry image showing staining of C57BL/6 splenocytes with 0.25 µg of Rat IgG2a ? Isotype Control Biotin (open histogram) or 0.25 µg of ab95712 (filled histogram) followed by Streptavidin PE. Cells in the lymphocyte gate were used for analysis.

プロトコール

参考文献

This product has been referenced in:
  • Vosshenrich CA  et al. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol 174:1213-21 (2005). Read more (PubMed: 15661875) »
  • Vincent P Factors influencing patient noncompliance: a theoretical approach. Nurs Res 20:509-16 (1971). Read more (PubMed: 5210829) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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