製品の概要
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製品名Anti-IL17RD antibody
IL17RD 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to IL17RD
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由来種Rabbit
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アプリケーション適用あり: WB, ICC/IFmore details
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種交差性交差種: Human
交差が予測される動物種: Mouse, Rat, Chicken
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免疫原
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 209 (Q8NFM7) of IL17 Receptor D
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ポジティブ･コントロール
- NT2D1, IMR32 whole cell lysate, U87-MG, MCF-7 cells.
法規制情報
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab111553 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 80 kDa. | |
| ICC/IF | 1/100 - 1/500. |
ターゲット情報
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機能Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis.
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組織特異性Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituarity, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.
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細胞内局在Cytoplasm and Golgi apparatus membrane. Cell membrane. Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
- Information by UniProt
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参照データベース
- Entrez Gene: 54756 Human
- Entrez Gene: 171463 Mouse
- Entrez Gene: 498576 Rat
- Omim: 606807 Human
- SwissProt: Q8NFM7 Human
- SwissProt: Q8JZL1 Mouse
- Unigene: 150725 Human
- Unigene: 206726 Mouse
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別名
- DKFZp434N1928 antibody
- FLJ35755 antibody
- hSef antibody
see all
画像
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Western blot - Anti-IL17RD antibody (ab111553)Anti-IL17RD antibody (ab111553) at 1/3000 dilution + IMR32 whole cell lysate at 30 µg
Predicted band size: 80 kDa
7.5% SDS PAGE -
Immunocytochemistry/ Immunofluorescence - Anti-IL17RD antibody (ab111553)Top: ab111553 at 1/500 dilution, staining IL17RD by ICC/IF (methanol-fixed MCF7 cells). Bottom: co-stained with Hoechst 33342.
参考文献
ab111553 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"