Anti-IL-17A 抗体 (ab91649)
Key features and details
- Rabbit polyclonal to IL-17A
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
製品の概要
-
製品名
Anti-IL-17A antibody
IL-17A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IL-17A -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
ポジティブ・コントロール
- Recombinant Mouse IL-17 protein (ab50162) can be used as a positive control in WB. This antibody gave a positive signal in a mouse lymph node section.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab91649の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
特記事項 |
---|
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
-
機能
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. -
組織特異性
Restricted to activated memory T-cells. -
配列類似性
Belongs to the IL-17 family. -
翻訳後修飾
Found both in glycosylated and nonglycosylated forms. -
細胞内局在
Secreted. - Information by UniProt
-
参照データベース
- Entrez Gene: 16171 Mouse
- Entrez Gene: 301289 Rat
- SwissProt: Q62386 Mouse
- SwissProt: Q61453 Rat
-
別名
- CTLA 8 antibody
- CTLA-8 antibody
- CTLA8 antibody
see all
画像
-
IHC image of IL-17A staining in mouse lymph node formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab91649, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (10)
ab91649 は 10 報の論文で使用されています。
- Azevedo MLV et al. Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19. Front Immunol 12:656350 (2021). PubMed: 33868301
- Lu L et al. V?4 T cell-derived IL-17A is essential for amplification of inflammatory cascades in ischemic brain tissue after stroke. Int Immunopharmacol 96:107678 (2021). PubMed: 34162129
- Choreño-Parra JA et al. Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1). Front Immunol 12:593595 (2021). PubMed: 33995342
- Chen J et al. The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice. Mediators Inflamm 2021:5551578 (2021). PubMed: 34093086
- Soley BDS et al. B1 and B2 kinin receptor blockade improves psoriasis-like disease. Br J Pharmacol N/A:N/A (2020). PubMed: 32335893
- Hsu PY et al. Cordycepin and a preparation fromCordyceps militarisinhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model. Oncotarget 8:93712-93728 (2017). PubMed: 29212184
- Cai S et al. IFN-? induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol 9:718-29 (2016). PubMed: 26349661
- Chou TF et al. Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1a for Th17 suppression. Nat Commun 7:11904 (2016). WB, IHC ; Human . PubMed: 27312851
- Patras KA et al. Characterization of host immunity during persistent vaginal colonization by Group B Streptococcus. Mucosal Immunol 8:1339-48 (2015). IHC . PubMed: 25850655
- Usategui A et al. A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis N/A:N/A (2013). IHC ; Mouse . PubMed: 23413283