製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to IL16
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to a sequence within amino acids 1268-1332 of Human IL16 (NP_757366).

  • ポジティブ・コントロール
    • A549, Jurkat and NT2D cells.

法規制情報

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab97405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 142 kDa.

ターゲット情報

  • 機能
    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • 組織特異性
    Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • 配列類似性
    Contains 4 PDZ (DHR) domains.
  • 翻訳後修飾
    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • 細胞内局在
    Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HGNC:5980 antibody
    • HsT19289 antibody
    • IL-16 antibody
    • IL16 antibody
    • IL16_HUMAN antibody
    • Interleukin 16 precursor antibody
    • Interleukin-16 antibody
    • LCF antibody
    • Lymphocyte chemoattractant factor antibody
    • Neuronal interleukin 16 antibody
    • NIL16 antibody
    • prIL 16 antibody
    • PrIL16 antibody
    • Prointerleukin 16 antibody
    see all

画像

  • Anti-IL16 antibody (ab97405) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 142 kDa

プロトコール

参考文献

ab97405 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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