Anti-IL15RA 抗体 [MM0369-5M53] (ab89894)

製品の概要

  • 製品名
    Anti-IL15RA antibody [MM0369-5M53]
    IL15RA 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0369-5M53] to IL15RA
  • 特異性
    ab89894 detects IL15RA.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment corresponding to the extracellular domain of Human IL15RA.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89894 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 28 kDa. WB ab89894 has been tested only against the immunogen and negative results were obtained in ELISA against mouse IL15RA.

ターゲット情報

  • 機能
    Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
  • 組織特異性
    Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
  • 配列類似性
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻訳後修飾
    A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
    Phosphorylated by activated SYK.
    N-glycosylated and O-glycosylated.
  • 細胞内局在
    Secreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AA690181 antibody
    • CD215 antibody
    • I15RA_HUMAN antibody
    • IL 15R alpha antibody
    • IL-15 receptor subunit alpha antibody
    • IL-15R-alpha antibody
    • IL-15RA antibody
    • Il15ra antibody
    • Interleukin 15 receptor alpha antibody
    • Interleukin 15 receptor subunit alpha antibody
    • MGC104179 antibody
    • sIL-15 receptor subunit alpha antibody
    • sIL-15R-alpha antibody
    • sIL-15RA antibody
    • Soluble interleukin 15 receptor subunit alpha antibody
    • Soluble interleukin-15 receptor subunit alpha antibody
    see all

プロトコール

Anti-IL15RA antibody [MM0369-5M53] (ab89894) 使用論文

ab89894 has not yet been referenced specifically in any publications.

Product Wall

Application
Western blot
Sample
Human Recombinant protein (hIL-15ra recombinant protein transduced into EL ce)
Loading amount
15 µg
Specification
hIL-15ra recombinant protein transduced into EL ce
Treatment
BME
Gel Running Conditions
Reduced Denaturing
Blocking step
Milk as blocking agent for 10 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 4°C
Username

Gong Yun

Verified customer

投稿 Jan 10 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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