Anti-IL12RB1 抗体 [MM0363-7V24] (ab89890)

製品の概要

  • 製品名Anti-IL12RB1 antibody [MM0363-7V24]
    IL12RB1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0363-7V24] to IL12RB1
  • 特異性ab89890 detects IL12RB1.
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment corresponding to the extracellular domain of Human IL12RB1.

製品の特性

  • 製品の状態Lyophilised:Reconstitute the antibody with 200 µl sterile PBS.
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • ポリ/モノモノクローナル
  • クローン名MM0363-7V24
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
  • 関連疾患Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • 配列類似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
  • ドメインThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD212 antibody
    • cluster of differentiation 212 antibody
    • I12R1_HUMAN antibody
    • IL-12 receptor beta component antibody
    • IL-12 receptor subunit beta-1 antibody
    • IL-12R subunit beta-1 antibody
    • IL-12R-beta-1 antibody
    • IL-12RB1 antibody
    • IL12 receptor beta component antibody
    • IL12RB antibody
    • Il12rb1 antibody
    • IMD3 antibody
    • IMD30 antibody
    • Interleukin 12 receptor beta 1 chain antibody
    • Interleukin 12 receptor subunit beta 1 antibody
    • Interleukin-12 receptor subunit beta-1 antibody
    • MGC34454 antibody
    see all

Anti-IL12RB1 antibody [MM0363-7V24] (ab89890) 使用論文

ab89890 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"