製品の概要

  • 製品名Anti-IL12 p40 antibody
    IL12 p40 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IL12 p40
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 23-328 of Human IL12 p40 (BC067499).

  • ポジティブ・コントロール
    • Human fetal liver lysate; Human fetal colon tissue.

製品の特性

  • 製品の状態Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab106270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/2000. Detects a band of approximately 46 kDa (predicted molecular weight: 37 kDa).
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
    Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • 関連疾患Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
    Genetic variations in IL12B are a cause of susceptibility to psoriasis type 11 (PSORS11) [MIM:612599]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
  • 配列類似性Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 翻訳後修飾Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CLMF antibody
    • CLMF p40 antibody
    • CLMF2 antibody
    • Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody
    • IL 12 subunit p40 antibody
    • IL 12B antibody
    • IL-12 subunit p40 antibody
    • IL-12B antibody
    • IL12 subunit p40 antibody
    • IL12B antibody
    • IL12B_HUMAN antibody
    • interleukin 12 beta chain antibody
    • Interleukin 12 p40 antibody
    • Interleukin 12 subunit beta antibody
    • Interleukin 12B antibody
    • Interleukin-12 subunit beta antibody
    • natural killer cell stimulatory factor 40 kD subunit antibody
    • NK cell stimulatory factor chain 2 antibody
    • NKSF antibody
    • NKSF2 antibody
    • p40 antibody
    see all

Anti-IL12 p40 antibody 画像

  • Anti-IL12 p40 antibody (ab106270) at 1/1000 dilution + Human fetal liver lysate

    Predicted band size : 37 kDa
  • ab106270 at 1/100 dilution staining IL12 p40 in Human fetal colon by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Anti-IL12 p40 antibody (ab106270) 使用論文

This product has been referenced in:
  • Helbling M  et al. Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients. Oncotarget 5:4671-82 (2014). Read more (PubMed: 25015728) »

See 1 Publication for this product

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Thank you for your enquiry. I can confirm we have the following IL-12 p40 antibodies available which have been tested in western blot.  I can recommend to review the online datasheets for further information, and to select one that has been tested and ...

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