Anti-IKKi/IKKe 抗体 - Carboxyterminal end (ab37596)

製品の概要

  • 製品名Anti-IKKi/IKKe antibody - Carboxyterminal end
    IKKi/IKKe 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IKKi/IKKe - Carboxyterminal end
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected within aa 700-800 of human IKKE.

  • ポジティブ・コントロール
    • 293 cell lysate, human breast carcinoma

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab37596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/1000. Detects a band of approximately 80 kDa (predicted molecular weight: 80 kDa).
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
  • 組織特異性Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
  • 配列類似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated.
    Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.
  • 細胞内局在Cytoplasm. Nucleus. Nucleus > PML body. Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent.
  • Information by UniProt
  • 参照データベース
  • 別名
    • I kappa B kinase epsilon antibody
    • I-kappa-B kinase epsilon antibody
    • IkBKE antibody
    • IKK related kinase epsilon antibody
    • IKK-E antibody
    • IKK-epsilon antibody
    • IKK-i antibody
    • IKKE antibody
    • IKKE_HUMAN antibody
    • IKKepsilon antibody
    • IKKI antibody
    • Inducible I kappa B kinase antibody
    • Inducible I kappa-B kinase antibody
    • Inducible IkappaB kinase antibody
    • Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon antibody
    • Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, epsilon antibody
    • Inhibitor of nuclear factor kappa-B kinase subunit epsilon antibody
    • KIAA0151 antibody
    • MGC125294 antibody
    • MGC125295 antibody
    • MGC125297 antibody
    see all

Anti-IKKi/IKKe antibody - Carboxyterminal end 画像

  • Anti-IKKi/IKKe antibody - Carboxyterminal end (ab37596) at 1/100 dilution + HEK293 cell lysate

    Predicted band size : 80 kDa
    Observed band size : 80 kDa
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemical analysis of IKKi/IKKe in formalin-fixed, paraffin-embedded human breast carcinoma with 1/50 ab37596.

Anti-IKKi/IKKe antibody - Carboxyterminal end (ab37596) 使用論文

ab37596 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (MCF 7)
Loading amount 15 µg
Specification MCF 7
Gel Running Conditions Reduced Denaturing (4-12% Bis Tris)
Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 25°C
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投稿 Aug 12 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"