IKK alpha peptide (ab7893)

関連情報

• 別名
  • chuk
  • CHUK1
  • Conserved Helix Loop Helix Ubiquitous Kinase

  • Conserved helix loop ubiquitous kinase
  • Conserved helix-loop-helix ubiquitous kinase
  • I Kappa B Kinase 1
  • I Kappa B Kinase Alpha
  • I-kappa-B kinase 1
  • I-kappa-B kinase alpha
  • IkappaB kinase
  • IkB kinase alpha subunit
  • IkBKA
  • IKK 1
  • IKK A
  • IKK a kinase
  • IKK-A
  • IKK-alpha
  • IKK1
  • IKKA
  • IKKA_HUMAN
  • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells
  • Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit
  • Inhibitor of nuclear factor kappa-B kinase subunit alpha
  • NFKBIKA
  • Nuclear Factor Kappa B Inhibitor Kinase Alpha
  • Nuclear factor NF kappa B inhibitor kinase alpha
  • Nuclear factor NF-kappa-B inhibitor kinase alpha
  • Nuclear factor NFkappaB inhibitor kinase alpha
  • Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor
  • TCF-16
  • TCF16
  • Transcription factor 16

  see all
• 機能Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
• 組織特異性Widely expressed.
• 関連疾患Defects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasement syndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
• 配列類似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
  Contains 1 protein kinase domain.
• 翻訳後修飾Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
  Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
• 細胞内局在Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.

• Target information above from: UniProt accession O15111 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt