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別名
- chuk
- CHUK1
- Conserved Helix Loop Helix Ubiquitous Kinase
- Conserved helix loop ubiquitous kinase
- Conserved helix-loop-helix ubiquitous kinase
- I Kappa B Kinase 1
- I Kappa B Kinase Alpha
- I-kappa-B kinase 1
- I-kappa-B kinase alpha
- IkappaB kinase
- IkB kinase alpha subunit
- IkBKA
- IKK 1
- IKK A
- IKK a kinase
- IKK-A
- IKK-alpha
- IKK1
- IKKA
- IKKA_HUMAN
- Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells
- Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- NFKBIKA
- Nuclear Factor Kappa B Inhibitor Kinase Alpha
- Nuclear factor NF kappa B inhibitor kinase alpha
- Nuclear factor NF-kappa-B inhibitor kinase alpha
- Nuclear factor NFkappaB inhibitor kinase alpha
- Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor
- TCF-16
- TCF16
- Transcription factor 16
see all
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機能
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
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組織特異性
Widely expressed.
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関連疾患
Defects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasement syndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
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配列類似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain.
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翻訳後修飾
Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
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細胞内局在
Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
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Information by UniProt