製品の概要

  • 製品名Anti-IGSF8 antibody
    IGSF8 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IGSF8
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 450 - 550 of Human IGSF8.

    (Peptide available as ab74889.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Human Brain Tissue Lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab74890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 65 kDa).

ターゲット情報

  • 機能May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
  • 組織特異性Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
  • 配列類似性Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • ドメインThe Ig-like C2-type domains 3 and 4 are required for interaction with CD81.
    The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD316 antibody
    • CD316 antigen antibody
    • CD81 partner 3 antibody
    • CD81P3 antibody
    • EWI-2 antibody
    • EWI2 antibody
    • Glu-Trp-Ile EWI motif-containing protein 2 antibody
    • igsf-8 antibody
    • IgSF8 antibody
    • IGSF8_HUMAN antibody
    • Immunoglobulin superfamily member 8 antibody
    • Immunoglobulin superfamily member 8 precursor antibody
    • KCT-4 antibody
    • KCT4 antibody
    • Keratinocytes-associated transmembrane protein 4 antibody
    • LIR-D1 antibody
    • PGRL antibody
    • Prostaglandin regulatory-like protein antibody
    see all

Anti-IGSF8 antibody 画像

  • Anti-IGSF8 antibody (ab74890) at 1 µg/ml + Human brain tissue lysate - total protein (ab29466) at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 65 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)


    Exposure time : 20 minutes

Anti-IGSF8 antibody (ab74890) 使用論文

This product has been referenced in:
  • Liang Y  et al. Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. J Biol Chem 289:32526-37 (2014). Read more (PubMed: 25261472) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab74890.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"