Anti-IgM 抗体, prediluted (ab75669)

製品の概要

  • 製品名Anti-IgM antibody, prediluted
    IgM 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IgM, prediluted
  • 特異性This antibody recognizes the mu heavy chain of human immunoglobulins. It does not cross-react with gamma (IgG), alpha (IgA), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes.
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length human IgM protein purified from serum of a patient with Waldenstrom's Macroglobulinaemia.

  • ポジティブ・コントロール
    • Human tonsil tissue.
  • 特記事項


    This antibody can be useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas.

製品の特性

  • 製品の状態Prediluted
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 15mM Sodium Azide
    Constituents: 0.5 mol/L Tris HCl, pH 7.6, containing stabilizing protein
  • Concentration information loading...
  • 精製度Protein A purified
  • 一次抗体 備考This antibody can be useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab75669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/1. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Ready to use.

ターゲット情報

  • 関連性IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
  • 細胞内局在Isoform 1: Secreted. During differentiation, B lymphocytes switch from expression of membrane bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single pass type I membrane protein.
  • 参照データベース
  • 別名
    • AGM1 antibody
    • Constant region of heavy chain of IgM antibody
    • DKFZp686I15196 antibody
    • DKFZp686I15212 antibody
    • FLJ00385 antibody
    • Hepatitis B virus receptor binding protein antibody
    • Ig mu chain C region antibody
    • IGHM antibody
    • IgM heavy chain constant region antibody
    • Immunoglobulin heavy constant mu antibody
    • Immunoglobulin mu chain antibody
    • Imunoglobulin heavy chain antibody
    • Imunoglobulin heavy chain constant region mu antibody
    • Imunoglobulin heavy chain mu constant region antibody
    • MGC104996 antibody
    • MGC52291 antibody
    • MU antibody
    • VH antibody
    see all

Anti-IgM antibody, prediluted 画像

  • Formalin-fixed, paraffin-embedded human tonsil stained with ab75669, using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of IgM-secreting cells.

Anti-IgM antibody, prediluted (ab75669) 使用論文

ab75669 has not yet been referenced specifically in any publications.

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