製品の概要

  • 製品名Anti-IgM antibody [KT16]
    IgM 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [KT16] to IgM
  • 特異性ab110653 does not cross-react with Human IgG and recombinant Human IgG1, IgG2, IgG3, IgG4, IgA and IgE.
  • アプリケーション適用あり: Indirect ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant Human IgM

  • ポジティブ・コントロール
    • Human serum

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab110653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Indirect ELISA Use a concentration of 1 µg/ml.
Sandwich ELISA Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with Mouse monoclonal [KT38] to IgM (HRP) (ab106742). Use ab106742 as the dection antibody and ab110653 as the capture antibody.

ターゲット情報

  • 関連性IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
  • 細胞内局在Isoform 1: Secreted. During differentiation, B lymphocytes switch from expression of membrane bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single pass type I membrane protein.
  • 参照データベース
  • 別名
    • AGM1 antibody
    • Constant region of heavy chain of IgM antibody
    • DKFZp686I15196 antibody
    • DKFZp686I15212 antibody
    • FLJ00385 antibody
    • Hepatitis B virus receptor binding protein antibody
    • Ig mu chain C region antibody
    • IGHM antibody
    • IgM heavy chain constant region antibody
    • Immunoglobulin heavy constant mu antibody
    • Immunoglobulin mu chain antibody
    • Imunoglobulin heavy chain antibody
    • Imunoglobulin heavy chain constant region mu antibody
    • Imunoglobulin heavy chain mu constant region antibody
    • MGC104996 antibody
    • MGC52291 antibody
    • MU antibody
    • VH antibody
    see all

Anti-IgM antibody [KT16] 画像

  • Sandwich ELISA for purified IgM using ab110653 coated plate and HRP conjugated ab106742. IgE is a negative control.
  • Sandwich ELISA for Human serum using ab110653 coated plate and HRP conjugated ab106742.

Anti-IgM antibody [KT16] (ab110653) 使用論文

ab110653 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"