製品の概要

  • 製品名Anti-IGFBP3 antibody
    IGFBP3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IGFBP3
  • 特異性Recognizes human IGFBP 3. Slight crossreactivity with other IGF binding proteins: IGFBP 1: ~10%, IGFBP 2: <0.2%, IGFBP 4: <0.2%, IGFBP 5: <0.2%.
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
    非交差種: Rat, Horse, Cow, Pig
  • 免疫原

    Recombinant full length protein (Human IGFBP 3 expressed in CHO cells).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab4248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/250 - 1/1000. Predicted molecular weight: 40 kDa.
IP Use at an assay dependent dilution.

ターゲット情報

  • 機能IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 組織特異性Expressed by most tissues. Present in plasma.
  • 配列類似性Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • 発生段階IGFBP3 levels are higher during extrauterine life and peak during puberty.
  • ドメインThe thyroglobulin type-1 domain mediates interaction with HN.
  • 翻訳後修飾Phosphorylation sites are present in the extracelllular medium.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acid stable subunit of the 140 K IGF complex antibody
    • Binding protein 29 antibody
    • Binding protein 53 antibody
    • BP 53 antibody
    • BP53 antibody
    • Growth hormone dependent binding protein antibody
    • IBP 3 antibody
    • IBP-3 antibody
    • IBP3 antibody
    • IBP3_HUMAN antibody
    • IGF binding protein 3 antibody
    • IGF-binding protein 3 antibody
    • IGFBP 3 antibody
    • IGFBP-3 antibody
    • IGFBP3 antibody
    • Insulin Like Growth Factor Binding Protein 3 antibody
    • Insulin-like growth factor binding protein 3 precursor antibody
    • Insulin-like growth factor-binding protein 3 antibody
    see all

Anti-IGFBP3 antibody (ab4248) 使用論文

This product has been referenced in:
  • Walker G  et al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007). Read more (PubMed: 17332286) »

See 1 Publication for this product

Product Wall

Thank you for contacting us. We are happy to provide quote for 400 micro-litre of this antibody. The concentration of this antibody was not determined so we will be unable to give you quote for 400 µg. We generally do not determine the concentratio...

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Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (fibroblast)
Specification fibroblast
Fixative Formaldehyde
Permeabilization Yes - 0.5% triton for 5 min
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 4% · Temperature: 20°C
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Abcam user community

Verified customer

投稿 Jan 18 2008

Thank you for your patience in awaiting a response. Having discussed this issue with my colleagues and the originator of the product. The following may explain the route cause of the problem I have been told that in all cases, the IGFBP's are "stick...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"