Anti-IGF1 Receptor alpha subunit 抗体 [2C8] (ab987)


  • 製品名Anti-IGF1 Receptor alpha subunit antibody [2C8]
    IGF1 Receptor alpha subunit 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2C8] to IGF1 Receptor alpha subunit
  • 特異性This antibody reacts specifically with the IGF1 receptor alpha subunit.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Purified human placental IGF-1 receptors.



Our Abpromise guarantee covers the use of ab987 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報Dilute in PBS or medium which is identical to that used in the assay system.
    This antibody has no effect on the binding of IGF-1 or -2 to their receptor.
  • ターゲット情報

    • 関連性IGF1 Receptor is a tetramer of 2 alpha and 2 beta chains, linked by disulfide bonds. IGF1 Receptor, like insulin receptor, is synthesized as a single polypeptide which is glycosylated and proteolytically cleaved to give the alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity. It is assumed that, as for the insulin receptor, the tyrosine kinase activity is essential for IGF-1 action. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. It interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. IGF1 Receptor forms a hybrid receptor with INSR, the hybrid being a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R.
    • 細胞内局在Membrane; Single-pass type I membrane protein.
    • 参照データベース
    • 別名
      • CD221 antibody
      • CD221 antigen antibody
      • IGF I receptor antibody
      • IGFIR antibody
      • Insulin like growth factor I receptor antibody
      • JTK13 antibody
      see all

    Anti-IGF1 Receptor alpha subunit antibody [2C8] (ab987) 使用論文

    This product has been referenced in:
    • Li SL  et al. Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor. Biochem Biophys Res Commun 196:92-8 (1993). Read more (PubMed: 8216340) »

    See 1 Publication for this product

    Product Wall

    Thank you very much for your inquiry.

    Unfortunately, I cannot provide the publication from Li SL et. al., but I am happy to confirm that our lab has tested this antibody in WB in the following way:

    1. This antibody was tested on IGF...

    Read More

    Thank you for your enquiry and your interest in our products. We would like to confirm that ab986 and ab987 recognize human IGF-1 receptor. Please take a look at the information for immunogen used to raise these antibodies. We would also draw yo...

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    This antibody, #35103, recognizes the IGF-1 receptor. The molecular weight of the IGF-1 receptor is approx. 72 kD; the molecular weight of antibody #35103 is approx. 150 kD.