Anti-IgA Secretory Component 抗体 [SC-05 COMPO2] (ab17377)


  • 製品名Anti-IgA Secretory Component antibody [SC-05 COMPO2]
    IgA Secretory Component 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SC-05 COMPO2] to IgA Secretory Component
  • 特異性Ab17377 recognizes a human glycoprotein, identified as secretory component. Reacts with both free and polymeric Ig-bound secretory component. Shows no reaction in Western Blots of cell lines lacking secretory component. The clone number has been updated from (0.N.556) to (SC-05 COMPO2) both clone numbers name the same antibody clone.
  • アプリケーション適用あり: IHC-P, IHC-Fr, ICC/IFmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Full length protein corresponding to Human IgA Secretory Component. Semi-purified human secretory component

  • ポジティブ・コントロール
    • Small intestine, stomach, colon carcinoma



Our Abpromise guarantee covers the use of ab17377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 1 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 1 µg/ml.
ICC/IF Use at an assay dependent concentration.


  • 関連性IgA has two subclasses (IgA1 and IgA2) and can be produced as a monomeric as well as a dimeric form. The IgA dimeric form is the most prevalent and is also called secretory IgA (sIgA). The secretory component of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes, thus sIgA can survive in the harsh gastrointestinal tract environment and provide protection against microbes that multiply in body secretions. sIgA can also inhibit inflammatory effects of other immunoglobulins. Secretory component is a proteolytic cleavage product of the polymeric immunoglobulin receptor which remains associated with dimeric IgA in sero-mucus secretions. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen. Secretory components wrap around two IgA units joined by a J chain protein fragment, resulting in a >--< configuration, with each of the two antigen binding regions of the two constituent y-shaped antibodies exposed. One identified function of secretory components is to protect IgA antibodies from degradation by the gastric acids and enzymes of the digestive system. This property is especially important in the transfer of immune system components during breastfeeding.

Anti-IgA Secretory Component antibody [SC-05 COMPO2] (ab17377) 使用論文

ab17377 has not yet been referenced specifically in any publications.

Product Wall

I have had a look at the nature of this protein: Extracellular matrix protein 1 (

Unfortunately, I do not think it is scientifically to detect only ECM1b without detecting ECM1a.

The difference ...

Read More
Application Western blot
Loading amount 1 µg
Gel Running Conditions Non-reduced Non-Denaturing (Native)
Sample Human Recombinant protein (293T cells)
Specification 293T cells

Dr. Kye Hanafiah

Verified customer

投稿 Apr 18 2014


For Ab17377: ***
For Ab96196: ***

Expiration date: February 18, 2013

Value: $337 each

Each of these codes will give you $337 off your next order before the expiration date. To redeem this off...

Read More