製品の概要

  • 製品名
    Anti-IFT122 antibody
  • 製品の詳細
    Rabbit polyclonal to IFT122
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 667-883 of Human IFT122 (AAH03045).

  • ポジティブ・コントロール
    • 293T whole cell lysate; Hepatoma tissue.

法規制情報

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.75% Glycine, 1.21% Tris
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab111838 is purified by antigen-affinity chromatography.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG

アプリケーション

Our Abpromise guarantee covers the use of ab111838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 129 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. or Tris-EDTA buffer (pH 8.0)

ターゲット情報

  • 機能
    Required for cilia formation and Shh signaling during neuronal patterning.
  • 組織特異性
    Expressed in many tissues. Predominant expression in testis and pituitary.
  • 関連疾患
    Defects in IFT122 are a cause of cranioectodermal dysplasia type 1 (CED1) [MIM:218330]. CED1 is a disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include dolichocephaly (with or without sagittal suture synostosis), scaphocephaly, short stature, limb shortening, short ribs, narrow chest, brachydactyly, renal failure and hepatic fibrosis, small and abnormally shaped teeth, sparse hair, skin laxity and abnormal nails.
  • 配列類似性
    Contains 7 WD repeats.
  • 細胞内局在
    Cytoplasm. Cell projection > cilium. Cytoplasm > cytoskeleton > cilium basal body. Localizes to photoreceptor connecting cilia.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CED antibody
    • IF122_HUMAN antibody
    • IFT122 antibody
    • Intraflagellar transport 122 homolog (Chlamydomonas) antibody
    • Intraflagellar transport protein 122 homolog antibody
    • SPG antibody
    • WD repeat domain 10 antibody
    • WD repeat-containing protein 10 antibody
    • WD repeat-containing protein 140 antibody
    • WDR10 antibody
    • WDR10p antibody
    • WDR140 antibody
    see all

画像

  • Anti-IFT122 antibody (ab111838) at 1/1000 dilution + 293T cell line lysate at 30 µg

    Predicted band size : 129 kDa
  • ab111838, at 1/500 dilution, staining IFT122 in Formalin-fixed, Paraffin-embedded Hepatoma tissue by Immunohistochemistry.

参考文献

ab111838 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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