Anti-IFNGR1 (phospho Y457) 抗体 (ab61062)

製品の概要

• 製品名
  Anti-IFNGR1 (phospho Y457) antibody
  IFNGR1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to IFNGR1 (phospho Y457)
• 特異性
  ab61062 detects endogenous levels of IFNGR1 only when phosphorylated at tyrosine 457.
• アプリケーション
  適用あり: WB, IHC-P, ELISAmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse
• 免疫原

  Synthetic phosphopeptide derived from human IFNGR1 around the phosphorylation site of tyrosine 457 (GY^pDKP).

• ポジティブ･コントロール
  • Human brain tissue, COS7 cell extract.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  ab61062 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

  • Immunology
  • Innate Immunity
  • Cytokines
  • Interferons

  • Microbiology
  • Interspecies Interaction
  • Host Virus Interaction

  • Stem Cells
  • Hematopoietic Progenitors
  • Surface Molecules

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • B Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • NK Cell Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Dendritic Cell Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Monocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Neutrophil Lineage

  • Microbiology
  • Interspecies Interaction
  • Disease

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
• 関連疾患
  Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
• 配列類似性
  Belongs to the type II cytokine receptor family.
  Contains 2 fibronectin type-III domains.
  Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
• 翻訳後修飾
  Phosphorylated at Ser/Thr residues.
• 細胞内局在
  Membrane.

• Target information above from: UniProt accession P15260 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 3459 Human
  • Entrez Gene: 15979 Mouse
  • Omim: 107470 Human
  • SwissProt: P15260 Human
  • SwissProt: P15261 Mouse
  • Unigene: 520414 Human
  • Unigene: 549 Mouse
• 別名
  • Antiviral Protein Type II antibody
  • Antiviral protein, type 2 antibody
  • AVP type II antibody

  • AVP, type 2 antibody
  • CD 119 antibody
  • CD119 antibody
  • CD119 antigen antibody
  • CDw119 antibody
  • FLJ45734 antibody
  • IFN gamma R alpha antibody
  • IFN gamma R antibody
  • IFN gamma R1 antibody
  • IFN-gamma receptor 1 antibody
  • IFN-gamma-R1 antibody
  • IFNG R1 antibody
  • IFNGR 1 antibody
  • IFNGR antibody
  • IFNGR1 antibody
  • Immune interferon receptor 1 antibody
  • Immune interferon receptor for antibody
  • INGR1_HUMAN antibody
  • Interferon gamma receptor 1 antibody
  • Interferon gamma receptor alpha chain antibody
  • Interferon gamma receptor alpha chain precursor antibody

  see all

プロトコール

• Western blot protocols
• Immunohistochemistry protocols