PE Anti-IFNGR1 抗体 [2E2] (ab95673)
Key features and details
- PE Armenian hamster monoclonal [2E2] to IFNGR1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
製品の概要
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製品名
PE Anti-IFNGR1 antibody [2E2]
IFNGR1 一次抗体 製品一覧 -
製品の詳細
PE Armenian hamster monoclonal [2E2] to IFNGR1 -
由来種
Armenian hamster -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Purified preparation of soluble recombinant Mouse IFNGR1 chain protein
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ポジティブ・コントロール
- Mouse BALB/c splenocytes
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
2E2 -
アイソタイプ
IgG -
研究分野
関連製品
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95673の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt |
Use 1µg for 105 cells.
Cell number should be determined empirically but can range from 105 to 108 cells/test (based on a test volume of 100 µl).
ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
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特記事項 |
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Flow Cyt
Use 1µg for 105 cells. Cell number should be determined empirically but can range from 105 to 108 cells/test (based on a test volume of 100 µl).
ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
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ターゲット情報
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機能
Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. -
関連疾患
Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. -
配列類似性
Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
翻訳後修飾
Phosphorylated at Ser/Thr residues. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 15979 Mouse
- SwissProt: P15261 Mouse
- Unigene: 549 Mouse
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別名
- Antiviral Protein Type II antibody
- Antiviral protein, type 2 antibody
- AVP type II antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (0)
ab95673 は論文での使用が確認できていません。