製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to IFNAR2
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    SYDSPDYTDESCT

    , corresponding to internal sequence amino acids 28-40 of Human IFNAR2 (NP_000865.2 ; NP_997467.1; NP_997468.1).

  • ポジティブ・コントロール
    • Human Placenta and Prostate tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab104451 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
  • 組織特異性
    Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
  • 配列類似性
    Belongs to the type II cytokine receptor family.
  • 翻訳後修飾
    Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
    Glycosylated.
  • 細胞内局在
    Secreted and Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Human interferon alpha/beta receptor antibody
    • IFN alpha REC antibody
    • IFN R antibody
    • IFN-a/ßR2 antibody
    • IFN-a/ßRß antibody
    • IFN-alpha binding protein antibody
    • IFN-alpha/beta receptor 2 antibody
    • IFN-R-2 antibody
    • IFNABR antibody
    • IFNAR2 antibody
    • IFNARB antibody
    • IFNR antibody
    • INAR2_HUMAN antibody
    • Interferon (alpha beta and omega) receptor 2 antibody
    • Interferon alpha binding protein antibody
    • Interferon alpha/beta receptor 2 antibody
    • Interferon alpha/beta receptor beta chain antibody
    • Type I interferon receptor 2 antibody
    • Type I interferon receptor antibody
    see all

画像

  • ab104451, at 5 µg/ml, staining IFNAR2 in formalin-fixed, paraffin-embedded Human Placenta by Immunohistochemistry, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab104451, at 5 µg/ml, staining IFNAR2 in formalin-fixed, paraffin-embedded Human Prostate by Immunohistochemistry, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

プロトコール

参考文献

ab104451 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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