製品の概要

  • 製品名Anti-IFN gamma Receptor beta antibody
    IFN gamma Receptor beta 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IFN gamma Receptor beta
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human, Pig
    交差が予測される動物種: Cow, Baboon, Deer
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 250 to the C-terminus of Human IFN gamma Receptor beta.

    (Peptide available as ab90070.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in the following lysates: Tissues: Human spinal cord; Mouse liver; Human skeletal muscle; Mouse kidney. Whole cell: Hela nuclear; F9; A431

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 38 kDa).

ターゲット情報

  • 機能Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
  • 関連疾患Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • 配列類似性Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AF 1 antibody
    • AF-1 antibody
    • AF1 antibody
    • IFGR 2 antibody
    • IFGR2 antibody
    • IFN-gamma receptor 2 antibody
    • IFN-gamma-R2 antibody
    • IFNGR 2 antibody
    • IFNGR2 antibody
    • IFNGT 1 antibody
    • IFNGT1 antibody
    • IMD28 antibody
    • INGR2_HUMAN antibody
    • Interferon gamma receptor 2 (interferon gamma transducer 1) antibody
    • Interferon gamma receptor 2 antibody
    • Interferon gamma receptor accessory factor 1 antibody
    • Interferon gamma receptor beta chain antibody
    • Interferon gamma receptor chain 2 antibody
    • Interferon gamma transducer 1 antibody
    see all

Anti-IFN gamma Receptor beta antibody 画像

  • All lanes : Anti-IFN gamma Receptor beta antibody (ab77246) at 1 µg/ml

    Lane 1 : Human spinal cord tissue lysate - total protein (ab29188)
    Lane 2 : Liver (Mouse) Tissue Lysate
    Lane 3 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate
    Lane 4 : F9 (Mouse embryonic carcinoma cell line)
    Lane 5 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 6 : Human skeletal muscle tissue lysate - total protein (ab29330)
    Lane 7 : Kidney (Mouse) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 38 kDa
    Observed band size : 49 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 16 kDa,48 kDa (possible cleavage fragment),77 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes

Anti-IFN gamma Receptor beta antibody (ab77246) 使用論文

This product has been referenced in:
  • Ionescu VA  et al. Cultured adult porcine astrocytes and microglia express functional interferon-? receptors and exhibit toxicity towards SH-SY5Y cells. Brain Res Bull : (2010). ICC/IF ; Pig . Read more (PubMed: 21185917) »

See 1 Publication for this product

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