Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist (ab120111)
Key features and details
- GluN2B (formerly NR2B)-preferring NMDA antagonist
- CAS Number: 23210-58-4
- Soluble in water to 15 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist -
製品の詳細
GluN2B (formerly NR2B)-preferring NMDA antagonist -
生理活性の詳細
Non-competitive NMDA receptor antagonist acting at the polyamine site. Displays GluN2B (formerly NR2B) subunit selectivity. IC50 values are 0.15 μM at NR1/NR2B and >30 μM for NR1/NR2A, NR1/NR2C and NR1/NR2D receptors.
Also available in simple stock solutions (ab146675) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
23210-58-4 -
構造式
製品の特性
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体系名
erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate -
分子量
400.49 -
分子式
C21H27NO2.0.5C4H6O6 -
PubChem 登録番号
656586 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 15 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O -
由来
Synthetic
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研究分野
関連製品
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Related Products
画像
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2D chemical structure image of ab120111, Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist
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Median ifenprodil sensitivity from a rat postnatal day 2 (P2) and day 12 (P12) neuron; NMDAR-mediated responses in control (black) and in presence of the GluN2B-preferring antagonist ifenprodil (ab120111, grey).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (11)
ab120111 は 11 報の論文で使用されています。
- Li Y et al. Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension through Suppression of MEK/ERK/CREB Pathway. Am J Hypertens N/A:N/A (2021). PubMed: 33856436
- Taoro-Gonzalez L et al. Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms. J Neuroinflammation 15:36 (2018). PubMed: 29422059
- Yu YJ et al. Involvement of protein phosphatases in the destabilization of methamphetamine-associated contextual memory. Learn Mem 23:486-93 (2016). PubMed: 27531839
- Yang Y & Xu-Friedman MA Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol 113:3634-45 (2015). PubMed: 25855696
- Tovar KR et al. Triheteromeric NMDA receptors at hippocampal synapses. J Neurosci 33:9150-60 (2013). PubMed: 23699525