Anti-ICOS 抗体 [15F9] (Phycoerythrin) (ab95629)

製品の概要

• 製品名
  Anti-ICOS antibody [15F9] (Phycoerythrin)
  ICOS 一次抗体 製品一覧
• 製品の詳細
  Syrian Hamster monoclonal [15F9] to ICOS (Phycoerythrin)
• 標識
  Phycoerythrin. Ex: 488nm, Em: 575nm
• アプリケーション
  適用あり: Flow Cytmore details
• 種交差性
  交差種: Mouse
  
• 免疫原

  Full length Mouse ICOS protein.

• ポジティブ･コントロール
  • Mouse ConA activated spleen cell suspensions

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C.
• バッファー
  Preservative: 0.09% Sodium Azide
  Constituents: PBS, 150mM Sodium chloride, pH 7.2
• Concentration information loading...
• 精製度
  Protein G purified
• ポリ/モノ
  モノクローナル
• クローン名
  15F9
• アイソタイプ
  IgG
• 研究分野
  • Immunology
  • Adaptive Immunity
  • T Cells
  • CD

アプリケーション

ターゲット情報

• 機能
  Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
• 組織特異性
  Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
• 関連疾患
  Immunodeficiency, common variable, 1
• 配列類似性
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• 翻訳後修飾
  N-glycosylated.
• 細胞内局在
  Secreted and Cell membrane.

• Target information above from: UniProt accession Q9Y6W8 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 54167 Mouse
  • SwissProt: Q9WVS0 Mouse
  • Unigene: 42044 Mouse
• 別名
  • Activation inducible lymphocyte immunomediatory molecule antibody
  • Activation-inducible lymphocyte immunomediatory molecule antibody
  • AILIM antibody

  • CD278 antibody
  • CD278 antigen antibody
  • CD28-related Protein-1 antibody
  • CRP1 antibody
  • CVID1 antibody
  • ICOS antibody
  • ICOS_HUMAN antibody
  • Inducible costimulator antibody
  • Inducible T cell co stimulator antibody
  • Inducible T-cell costimulator antibody
  • MGC39850 antibody

  see all

プロトコール

• Flow cytometry protocols