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機能
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
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組織特異性
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
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関連疾患
Immunodeficiency, common variable, 1
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配列類似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
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翻訳後修飾
N-glycosylated.
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細胞内局在
Secreted and Cell membrane.
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Information by UniProt
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参照データベース
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別名
- Activation inducible lymphocyte immunomediatory molecule antibody
- Activation-inducible lymphocyte immunomediatory molecule antibody
- AILIM antibody
- CD278 antibody
- CD278 antigen antibody
- CD28-related Protein-1 antibody
- CRP1 antibody
- CVID1 antibody
- ICOS antibody
- ICOS_HUMAN antibody
- Inducible costimulator antibody
- Inducible T cell co stimulator antibody
- Inducible T-cell costimulator antibody
- MGC39850 antibody
see all