The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報Flow Cyt: Use 20µl for 106 cells cells in a suspension or 100µl of whole blood.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
配列類似性Belongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
翻訳後修飾Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Woollard KJ et al. Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation. Circ Res103:1128-38 (2008).
Read more (PubMed: 18818407) »