製品の概要

  • 製品名Iberiotoxin
  • 製品の詳細
    Selective blocker of the high-conductance, Ca2+-activated K+ channel
  • 生理活性の詳細Selective blocker of the high-conductance, Ca2+-activated K+ channel. Originally isolated from the scorpion Mesobuthus tamulus. Specifically blocks KCa1.1 (Slo) channels (Ki approx. 1 nM).
  • 精製度> 95%

製品の特性

    Iberiotoxin 画像

    • HEK293 cells plated for 48 hours and then transfected with rat Slo27 for 24 hours. Currents from whole-cell recordings, with 1 µM Ca2+ in the electrode solution. Cells voltage-clamped at -80 mV, with currents activated by 500 ms depolarization to +20 mV. Concentration-inhibition relationship produces an IC50 of 412 pM.

      (Number of experimental determinations shown in brackets).

    Iberiotoxin (ab120379) 使用論文

    This product has been referenced in:
    • Meera P  et al. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Proc Natl Acad Sci U S A 97:5562-7 (2000). Read more (PubMed: 10792058) »
    • Koschak A  et al. [125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels. Biochemistry 36:1943-52 (1997). Read more (PubMed: 9048582) »
    • Garcia ML  et al. Use of toxins to study potassium channels. J Bioenerg Biomembr 23:615-46 (1991). Read more (PubMed: 1917911) »

    See all 2 Publications for this product

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