製品の概要

  • 製品名Anti-HVCN1 antibody
    HVCN1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HVCN1
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids of Human HVCN1 (NP_115745.2).

  • ポジティブ・コントロール
    • Human spleen and thymus tissues.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab117520 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 32 kDa.Can be blocked with HVCN1 peptide (ab214795).
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
  • 組織特異性Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
  • 配列類似性Belongs to the hydrogen channel family.
  • ドメインThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.
    The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.
  • 翻訳後修飾Phosphorylation may enhance channel gating.
  • 細胞内局在Membrane. Cell membrane. Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HV 1 antibody
    • HV1 antibody
    • HVCN 1 antibody
    • HVCN1 antibody
    • HVCN1_HUMAN antibody
    • Hydrogen voltage gated channel 1 antibody
    • Hydrogen voltage-gated channel 1 antibody
    • Voltage gated hydrogen channel 1 antibody
    • Voltage sensor domain only protein antibody
    • Voltage sensor domain-only protein antibody
    • Voltage-gated hydrogen channel 1 antibody
    • VSOP antibody
    see all

Anti-HVCN1 antibody 画像

  • ab117520, at 5 µg/ml, staining HVCN1 in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry.
  • ab117520, at 5 µg/ml, staining HVCN1 in Formalin-fixed, Paraffin-embedded Human thymus tissue by Immunohistochemistry.

Anti-HVCN1 antibody (ab117520) 使用論文

ab117520 has not yet been referenced specifically in any publications.

Product Wall

I am sorry for any confusion.

This protocol is provided from the lab which supplies ab117520 directly to us. It is the same protocol they use to test all their antibodies in IHC butrest assured it is not arandom protocol from IHC world.
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Thank you for your enquiry. Below please find the IHC protocol requested.

I hope this is helpful. Please contact me again if you have any further questions.

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Tissue Preparation

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"