Anti-Huntingtin Interacting Protein HIP1 抗体 [1B11] (ab90341)

製品の概要

  • 製品名Anti-Huntingtin Interacting Protein HIP1 antibody [1B11]
    Huntingtin Interacting Protein HIP1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [1B11] to Huntingtin Interacting Protein HIP1
  • アプリケーション適用あり: WB, ELISA, IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Recombinant fragment corresponding to C terminal half of Human Huntingtin Interacting Protein HIP1.

  • ポジティブ・コントロール
    • PC-3 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.01% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名1B11
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.125 µg/ml. Predicted molecular weight: 116 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 機能Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • 組織特異性Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
  • 関連疾患Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
  • 配列類似性Belongs to the SLA2 family.
    Contains 1 ENTH (epsin N-terminal homology) domain.
    Contains 1 I/LWEQ domain.
  • ドメインThe pseudo DED region (pDED) mediates the interaction with IFT57.
    Binds F-actin via the talin-like I/LWEQ domain.
  • 細胞内局在Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2610109B09Rik antibody
    • A930014B11Rik antibody
    • E130315I21Rik antibody
    • HIP 1 antibody
    • HIP I antibody
    • HIP-1 antibody
    • HIP-I antibody
    • hip1 antibody
    • HIP1/PDGFRB fusion gene antibody
    • HIP1/PDGFRB fusion gene, included antibody
    • HIP1_HUMAN antibody
    • HIPI antibody
    • Huntingtin interacting protein 1 antibody
    • Huntingtin-interacting protein 1 antibody
    • Huntingtin-interacting protein I antibody
    • ILWEQ antibody
    • KIAA4113 antibody
    • MGC126506 antibody
    • MGC27616 antibody
    • mKIAA4113 antibody
    see all

Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] 画像

  • All lanes : Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] (ab90341) at 0.125 µg/ml

    Lane 1 : PC-3 cell lysate
    Lane 2 : Recombinant protein at 0.02 µg
    Lane 3 : Recombinant protein at 0.04 µg


    Predicted band size : 116 kDa

Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] (ab90341) 使用論文

ab90341 has not yet been referenced specifically in any publications.

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