Anti-Huntingtin 抗体 - C-terminal (ab83915)


  • 製品名Anti-Huntingtin antibody - C-terminal
    Huntingtin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Huntingtin - C-terminal
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to a C terminal region of human Huntingtin

  • ポジティブ・コントロール
    • Mouse brain extract.


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.40
    Constituents: 30% Glycerol, 0.42% Potassium phosphate, 0.88% Sodium chloride
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab83915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 348 kDa.
ELISA Use at an assay dependent dilution.


  • 機能May play a role in microtubule-mediated transport or vesicle function.
  • 組織特異性Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.
  • 関連疾患Defects in HTT are the cause of Huntington disease (HD) [MIM:143100]. HD is an autosomal dominant neurodegenerative disorder characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia. Onset of the disease occurs usually in the third or fourth decade of life and symptoms progressively worsen leading to death in 10 to 20 years. Onset and clinical course depend on the degree of poly-Gln repeat expansion, longer expansions resulting in earlier onset and more severe clinical manifestations. HD affects 1 in 10,000 individuals of European origin. Neuropathology of Huntington disease displays a distinctive pattern with loss of neurons, especially in the caudate and putamen (striatum).
  • 配列類似性Belongs to the huntingtin family.
    Contains 10 HEAT repeats.
  • ドメインThe N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations.
  • 翻訳後修飾Cleaved by apopain downstream of the polyglutamine stretch. The resulting N-terminal fragment is cytotoxic and provokes apoptosis.
    Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation.
  • 細胞内局在Cytoplasm. Nucleus. The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington's disease neurons.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI256365 antibody
    • C430023I11Rik antibody
    • HD antibody
    • HD protein antibody
    • HD_HUMAN antibody
    • HDH antibody
    • HTT antibody
    • Huntingtin antibody
    • HUNTINGTON CHOREA antibody
    • Huntington disease protein antibody
    • Huntington's disease protein homolog antibody
    • IT 15 antibody
    • IT15 antibody
    • OTTMUSP00000026909 antibody
    • ZHD antibody
    see all

Anti-Huntingtin antibody - C-terminal 画像

  • All lanes : Anti-Huntingtin antibody - C-terminal (ab83915) at 0.1 µg/ml

    Lane 1 : mouse brain extract
    Lane 2 : mouse brain extract with blocking peptide at 1 µg/ml

    Predicted band size : 348 kDa
    Observed band size : 348 kDa

Anti-Huntingtin antibody - C-terminal (ab83915) 使用論文

ab83915 has not yet been referenced specifically in any publications.

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