Human ZO1 tight junction protein peptide (ab93087)

製品の概要

  • 製品名Human ZO1 tight junction protein peptide

製品の詳細

  • 由来Synthetic

特性

Our Abpromise guarantee covers the use of ab93087 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 精製度70 - 90% by HPLC.

  • 製品の状態Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • Tight junction protein 1
    • Tight junction protein ZO-1
    • Tight junction protein ZO1
    • TJP1
    • zo-1
    • Zo1
    • ZO1_HUMAN
    • Zona occludens 1
    • Zona occludens 1 protein
    • Zona occludens protein 1
    • Zonula occludens 1 protein
    • Zonula occludens protein 1
    see all
  • 機能The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions.
  • 組織特異性The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
  • 配列類似性Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.
    Contains 1 ZU5 domain.
  • ドメインThe second PDZ domain mediates interaction with GJA12.
  • 翻訳後修飾Phosphorylated. Dephosphorylated by PTPRJ.
  • 細胞内局在Cell membrane. Cell junction > tight junction. Movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact.
  • Information by UniProt

Human ZO1 tight junction protein peptide (ab93087) 使用論文

ab93087 has not yet been referenced specifically in any publications.

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