製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列KISPLHHLQMECSP
    • 領域773 to 786

関連製品

特性

Our Abpromise guarantee covers the use of ab23054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-USP6 antibody (ab4553)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Deubiquitinating enzyme 6
    • HRP1
    • Proto-oncogene TRE-2
    • TRE17
    • TRE2
    • Ubiquitin carboxyl-terminal hydrolase 6
    • Ubiquitin specific protease 6
    • Ubiquitin thiolesterase 6
    • Ubiquitin-specific-processing protease 6
    • UBP6_HUMAN
    • USP6
    see all
  • 機能Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
  • 組織特異性Testis specific. Expressed in various cancer cell lines.
  • 関連疾患Note=A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
  • 配列類似性Belongs to the peptidase C19 family.
    Contains 1 Rab-GAP TBC domain.
  • ドメインThe Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6.
  • 翻訳後修飾Monubiquitinated; ubiquitination is calmodulin and calcium dependent.
  • 細胞内局在Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
  • Information by UniProt

Human USP6 peptide (ab23054) 使用論文

ab23054 has not yet been referenced specifically in any publications.

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