製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      AEGGGCRERPDAE
    • 領域
      2 to 14

特性

Our Abpromise guarantee covers the use of ab23051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Deubiquitinating enzyme 4
    • MGC149848
    • MGC149849
    • Proto oncogene
    • Protooncogene
    • Ubiquitin carboxyl terminal hydrolase 4
    • Ubiquitin carboxyl-terminal hydrolase 4
    • Ubiquitin specific peptidase 4
    • Ubiquitin specific peptidase 4 (proto oncogene)
    • Ubiquitin specific peptidase 4 (protooncogene)
    • Ubiquitin specific processing protease 4
    • Ubiquitin specific protease 4
    • Ubiquitin specific protease 4 (proto oncogene)
    • Ubiquitin specific protease 4 (protooncogene)
    • Ubiquitin specific protease proto oncogene
    • Ubiquitin specific protease protooncogene
    • Ubiquitin thioesterase 4
    • Ubiquitin thiolesterase 4
    • Ubiquitin-specific-processing protease 4
    • Ubiquitous nuclear protein homolog
    • UBP4_HUMAN
    • UNP
    • UNPH
    • USP 4
    • USP4
    see all
  • 機能
    Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
  • 組織特異性
    Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
  • 配列類似性
    Belongs to the peptidase C19 family. USP4 subfamily.
    Contains 1 DUSP domain.
  • 翻訳後修飾
    Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
  • 細胞内局在
    Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.
  • Information by UniProt

参考文献

ab23051 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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