製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      GKKRTKGKTVPIDD-C
    • 領域
      2 to 15

関連製品

特性

Our Abpromise guarantee covers the use of ab23059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-USP16 antibody (ab4853)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Deubiquitinating enzyme 16
    • Human ubiquitin processing protease
    • MSTP039
    • Ubiquitin carboxyl-terminal hydrolase 16
    • Ubiquitin Specific peptidase 16
    • Ubiquitin Specific Protease 16
    • Ubiquitin thiolesterase 16
    • Ubiquitin-processing protease UBP-M
    • Ubiquitin-specific-processing protease 16
    • UBP M
    • UBP16_HUMAN
    • UBPM
    • usp16
    see all
  • 機能
    Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
  • 組織特異性
    Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 関連疾患
    Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
  • 配列類似性
    Belongs to the peptidase C19 family. USP16 subfamily.
    Contains 1 UBP-type zinc finger.
  • ドメイン
    The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.
  • 翻訳後修飾
    Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The phosphorylated form of the protein is also enzymatically active.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

参考文献

ab23059 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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