製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      NSNVENLPPHIIR-C
    • 領域
      2 to 14

特性

Our Abpromise guarantee covers the use of ab23035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • AA409170
    • E2 EPF
    • E2-EPF
    • E2EPF
    • EPF5
    • MGC101982
    • Ube2s
    • UBE2S_HUMAN
    • Ubiquitin carrier protein S
    • Ubiquitin conjugating enzyme E2 24 kD
    • Ubiquitin conjugating enzyme E2 24 kDa
    • Ubiquitin conjugating enzyme E2 EPF5
    • Ubiquitin conjugating enzyme E2 S
    • Ubiquitin conjugating enzyme E2S
    • Ubiquitin protein ligase S
    • Ubiquitin-conjugating enzyme E2 S
    • Ubiquitin-conjugating enzyme E2-24 kDa
    • Ubiquitin-conjugating enzyme E2-EPF5
    • Ubiquitin-protein ligase S
    see all
  • 機能
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Belongs to the ubiquitin-conjugating enzyme family.
  • 翻訳後修飾
    Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
  • Information by UniProt

参考文献

ab23035 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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