製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-QETYSKQVTSQEP
    • 領域
      167 to 179

関連製品

特性

Our Abpromise guarantee covers the use of ab22967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-UBE2C antibody (ab3935)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Cyclin selective ubiquitin carrier protein
    • dJ447F3.2
    • Mitotic specific ubiquitin conjugating enzyme
    • UB E2C
    • UBCH 10
    • UbcH10
    • UBE 2C
    • Ube2c
    • UBE2C_HUMAN
    • Ubiquitin carrier protein C
    • Ubiquitin carrier protein E2 C
    • Ubiquitin carrier protein E2C
    • Ubiquitin conjugating enzyme E2 C
    • Ubiquitin conjugating enzyme E2C
    • Ubiquitin protein ligase C
    • Ubiquitin-conjugating enzyme E2 C
    • Ubiquitin-protein ligase C
    see all
  • 機能
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Belongs to the ubiquitin-conjugating enzyme family.
  • 翻訳後修飾
    Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
  • Information by UniProt

参考文献

ab22967 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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