製品の概要

製品の詳細

  • 由来
    Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab101401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-TRP1 antibody (ab73873)

  • 精製度
    70 - 90% by HPLC.

  • 製品の状態
    Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • 5
    • 5,6 dihydroxyindole 2 carboxylic acid oxidase
    • 6-dihydroxyindole-2-carboxylic acid oxidase
    • b-PROTEIN
    • CAS2
    • Catalase B
    • CATB
    • DHICA oxidase
    • Glycoprotein 75
    • GP75
    • Melanoma antigen gp75
    • OCA3
    • TRP
    • TRP-1
    • TRP1
    • Tyrosinase related protein 1
    • Tyrosinase-related protein 1
    • TYRP
    • TYRP1
    • TYRP1_HUMAN
    • TYRRP
    see all
  • 機能
    Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
  • 組織特異性
    Pigment cells.
  • パスウェイ
    Pigment biosynthesis; melanin biosynthesis.
  • 関連疾患
    Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
  • 配列類似性
    Belongs to the tyrosinase family.
  • 細胞内局在
    Melanosome membrane.
  • Information by UniProt

参考文献

ab101401 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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