製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-KRLKSIEERQLLK
    • 領域
      1038 to 1050

関連製品

特性

Our Abpromise guarantee covers the use of ab45496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-TIF1 alpha antibody (ab38264)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

関連情報

  • 別名
    • E3 ubiquitin protein ligase TRIM24
    • E3 ubiquitin-protein ligase Trim24
    • hTIF1
    • PTC6
    • RING finger protein 82
    • RNF82
    • TF1A
    • TIF1
    • TIF1-alpha
    • TIF1A
    • TIF1A_HUMAN
    • TIF1ALPHA
    • Transcription intermediary factor 1-alpha
    • Transcriptional intermediary factor 1
    • Transcriptional intermediary factor 1 alpha
    • Trim24
    • Tripartite motif containing 24
    • Tripartite motif-containing protein 24
    see all
  • 機能
    Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 関連疾患
    Defects in TRIM24 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TRIM24/TIF1 is found in thyroid papillary carcinomas. Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene.
  • 配列類似性
    Contains 2 B box-type zinc fingers.
    Contains 1 bromo domain.
    Contains 1 PHD-type zinc finger.
    Contains 1 RING-type zinc finger.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Sumoylated.
  • 細胞内局在
    Nucleus. Cytoplasm. Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.
  • Information by UniProt

Human TIF1 alpha peptide (ab45496) 使用論文

ab45496 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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