製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      KETRNMVQRQFIA
    • 領域
      223 to 235

関連製品

特性

Our Abpromise guarantee covers the use of ab39885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The ab39885 peptide blocks antibodies that recognise amino acids 223-235 of human TICAM-2.
  • アプリケーション

    Western blot

    Blocking - Blocking peptide for Anti-TICAM2 antibody (ab17221)

  • 製品の状態
    Liquid
  • 備考
    Stable for at least 1 year at -20°C.The ab39885 peptide blocks antibodies that recognise amino acids 223-235 of human TICAM-2.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • Putative NF-kappa-B-activating protein 502
    • TCAM2_HUMAN
    • TICAM-2
    • TICAM2
    • TIR containing adapter molecule 2
    • TIR domain containing adaptor protein
    • TIR domain-containing adapter molecule 2
    • TIRAP 3
    • TIRAP3
    • TIRAP3a short form
    • TIRP
    • Toll-like receptor adaptor protein 3
    • Toll/interleukin-1 receptor domain-containing protein
    • TRAM
    • TRIF-related adapter molecule
    see all
  • 機能
    Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 組織特異性
    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 配列類似性
    Contains 1 TIR domain.
  • ドメイン
    The TIR domain mediates the interaction with TRAF6.
  • 翻訳後修飾
    Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 細胞内局在
    Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt

参考文献

ab39885 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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