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別名
- Acrg embryonic lethality (mouse) minimal region ortholog
- Acrg embryonic lethality minimal region ortholog
- Acrg embryonic lethality mouse minimal region ortholog
- Akt substrate of 160 kDa
- AS 160
- AS160
- BUB2
- CDC16
- KIAA0603
- NIDDM5
- TBC (Tre 2 BUB2 CDC16) domain containing protein
- TBC Tre 2 BUB2 CDC16 domain containing protein
- TBC1 D4
- TBC1 domain family member 4
- Tbc1d4
- TBCD4_HUMAN
- Tre-2
see all
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機能
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
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組織特異性
Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T cells from patients with atopic dermatitis.
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配列類似性
Contains 2 PID domains.
Contains 1 Rab-GAP TBC domain.
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翻訳後修飾
Phosphorylated by AKT1; insulin-induced.
Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation.
Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.
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細胞内局在
Cytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
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Information by UniProt