製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-EEREKNWKEKKTTE
    • 領域572 to 585

関連製品

特性

Our Abpromise guarantee covers the use of ab22913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-SWAP70 antibody (ab2511)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • KIAA0640
    • 70kDa
    • AV235546
    • FLJ39540
    • HSPC321
    • SWA 70 protein
    • SWAP 70
    • SWAP switching B-cell complex 70kDa subunit
    • SWAP-70
    • SWAP70
    • Switch associated protein 70
    • Switch-associated protein 70
    • SWP70_HUMAN
    see all
  • 機能Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 組織特異性Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
  • 配列類似性Contains 1 PH domain.
  • ドメインThe PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
  • 翻訳後修飾Tyrosine-phosphorylated.
  • 細胞内局在Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
  • Information by UniProt

Human SWAP70 peptide (ab22913) 使用論文

ab22913 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"