製品の概要

  • 製品名Human SENP6 peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列AAGKSGGSAGEIT-C
    • 領域2 to 14

特性

Our Abpromise guarantee covers the use of ab23114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • 2810017C20Rik
    • FLJ11355
    • FLJ11887
    • KIAA0389
    • KIAA0797
    • SENP 6
    • Senp6
    • SENP6_HUMAN
    • Sentrin specific protease 6
    • Sentrin-specific protease 6
    • Sentrin/SUMO specific protease SENP6
    • Sentrin/SUMO-specific protease SENP6
    • SSP 1
    • SSP1
    • SUMO 1 specific protease
    • SUMO 1 specific protease 1
    • SUMO-1-specific protease 1
    • SUMO1 specific protease
    • SUMO1 specific protease 1
    • SUMO1/sentrin specific peptidase 6
    • SUSP 1
    • SUSP1
    see all
  • 機能Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
  • 組織特異性Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • パスウェイProtein modification; protein sumoylation.
  • 配列類似性Belongs to the peptidase C48 family.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human SENP6 peptide (ab23114) 使用論文

ab23114 has not yet been referenced specifically in any publications.

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