製品の概要

  • 製品名Human SCRIBBLE peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-VRPGRRGLGPVPS
    • 領域1618 to 1630

特性

Our Abpromise guarantee covers the use of ab23149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • CRIB 1
    • CRIB1
    • hScrib
    • LAP 4
    • LAP4
    • PDZ domain protein scribble
    • Protein LAP4
    • Protein scribble homolog
    • SCRB 1
    • SCRB1
    • Scrib
    • SCRIB 1
    • SCRIB_HUMAN
    • SCRIB1
    • Scribble
    • Scribble homolog 1
    • scribbled homolog (Drosophila)
    • Vartul
    see all
  • 機能Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
  • 組織特異性Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
  • 配列類似性Belongs to the LAP (LRR and PDZ) protein family.
    Contains 16 LRR (leucine-rich) repeats.
    Contains 4 PDZ (DHR) domains.
  • 翻訳後修飾Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
  • 細胞内局在Cell membrane. Cell junction > adherens junction. Cytoplasm. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
  • Information by UniProt

Human SCRIBBLE peptide (ab23149) 使用論文

ab23149 has not yet been referenced specifically in any publications.

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