製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列MSNADFAKLFLRK
    • 領域951 to 963

関連製品

特性

Our Abpromise guarantee covers the use of ab45492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-SART3 antibody (ab36137)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

関連情報

  • 別名
    • DSAP1
    • hSART 3
    • hSART-3
    • P100
    • P110
    • p110(nrb)
    • RP11 13G14
    • SART 3
    • SART-3
    • SART3
    • SART3_HUMAN
    • Squamous cell carcinoma antigen recognized by T cells 3
    • Squamous cell carcinoma antigen recognized by T-cells 3
    • Tat interacting protein of 110 kDa
    • Tat-interacting protein of 110 kDa
    • Tip110
    see all
  • 機能Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
  • 組織特異性Ubiquitously expressed.
  • 関連疾患Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.
  • 配列類似性Contains 8 HAT repeats.
    Contains 2 RRM (RNA recognition motif) domains.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
  • Information by UniProt

Human SART3 peptide (ab45492) 使用論文

ab45492 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"