製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列KELFTSEFEPAMQIDG
    • 領域541 to 556

関連製品

特性

Our Abpromise guarantee covers the use of ab39775 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-ROR alpha antibody (ab16367)

    Neutralising

  • 精製度> 90 % SDS-PAGE.
    This antibody is greater than 70% pure.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Double distilled water or equivalent after reconstitution.

関連情報

  • 別名
    • fhl2a
    • NR1F1
    • Nuclear receptor ROR-alpha
    • Nuclear receptor RZR-alpha
    • Nuclear receptor subfamily 1 group F member 1
    • RAR-related orphan receptor A
    • Retinoid-related orphan receptor-alpha
    • Rora
    • RORA_HUMAN
    • RZR-ALPHA
    • RZRA
    see all
  • 機能Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.
  • 組織特異性Widely expressed in a number of tissues.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 翻訳後修飾Phosphorylation by PKC in neurons inhibits transcriptional activity. Phosphorylated on Thr-216 by ERK2 in vitro.
    Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIASy but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1.
    Ubiquitinated. Ubiquitination is required for efficient transcriptional activity and is prevented by Hairless.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human ROR alpha peptide (ab39775) 使用論文

ab39775 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"