製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      CQQDWVVQRIGK
    • 領域
      102 to 113

特性

Our Abpromise guarantee covers the use of ab23002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • CKBBP 1
    • CKBBP1
    • CKII beta binding protein 1
    • CKII beta-binding protein 1
    • Rbx 2
    • Rbx2
    • RBX2_HUMAN
    • Regulator of cullins 2
    • RING box protein 2
    • RING finger protein 7
    • RING-box protein 2
    • RNF 7
    • RNF7
    • ROC 2
    • ROC2
    • SAG
    • Sensitive to apoptosis gene
    • Sensitive to apoptosis gene protein
    • Zinc RING finger protein SAG
    see all
  • 機能
    Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
  • 組織特異性
    Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Belongs to the RING-box family.
    Contains 1 RING-type zinc finger.
  • ドメイン
    The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
  • 翻訳後修飾
    Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt

参考文献

ab23002 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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