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別名
- E3 ubiquitin-protein ligase RNF6
- Ring finger protein (C3H2C3 type) 6
- Ring finger protein 6
- RING H2 protein
- RING H2 protein RNF6
- RNF 6
- RNF6
- RNF6_HUMAN
- SPG2
see all
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機能
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
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組織特異性
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
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パスウェイ
Protein modification; protein ubiquitination.
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関連疾患
Defects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
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配列類似性
Belongs to the RNF12 family.
Contains 1 RING-type zinc finger.
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発生段階
Expressed in embryo and adult testis.
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細胞内局在
Nucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.
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Information by UniProt