製品の概要
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製品名Human RNF6 peptide
RNF6 タンパク質・ペプチド 製品一覧
製品の詳細
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由来Synthetic
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アミノ酸配列
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生物種Human
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配列CRQPVLGSNIANNG
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領域672 to 685
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特性
Our Abpromise guarantee covers the use of ab23003 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Blocking
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製品の状態Liquid
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
関連情報
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別名
- E3 ubiquitin-protein ligase RNF6
- Ring finger protein (C3H2C3 type) 6
- Ring finger protein 6
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機能E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
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組織特異性Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
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パスウェイProtein modification; protein ubiquitination.
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関連疾患Defects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
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配列類似性Belongs to the RNF12 family.
Contains 1 RING-type zinc finger. -
発生段階Expressed in embryo and adult testis.
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細胞内局在Nucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.
- Information by UniProt
参考文献
ab23003 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"