Human RNF6 peptide (ab23003)

関連情報

• 別名
  • E3 ubiquitin-protein ligase RNF6
  • Ring finger protein (C3H2C3 type) 6
  • Ring finger protein 6

  • RING H2 protein
  • RING H2 protein RNF6
  • RNF 6
  • RNF6
  • RNF6_HUMAN
  • SPG2

  see all
• 機能
  E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
• 組織特異性
  Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
• パスウェイ
  Protein modification; protein ubiquitination.
• 関連疾患
  Defects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
• 配列類似性
  Belongs to the RNF12 family.
  Contains 1 RING-type zinc finger.
• 発生段階
  Expressed in embryo and adult testis.
• 細胞内局在
  Nucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.

• Target information above from: UniProt accession Q9Y252 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt