製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-EEVPLGQSIPRRRK
    • 領域
      1059 to 1072

関連製品

特性

Our Abpromise guarantee covers the use of ab22938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-RNF31/HOIP antibody (ab2919)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • E3 ubiquitin protein ligase RNF31
    • FLJ10111
    • FLJ23501
    • HOIL 1L interacting protein
    • HOIL-1-interacting protein
    • HOIL1L interacting protein
    • HOIP
    • RING finger protein 31
    • RNF31
    • RNF31_HUMAN
    • ZIBRA
    • Zinc in between ring finger ubiquitin associated domain
    • Zinc in-between-RING-finger ubiquitin-associated domain protein
    see all
  • 機能
    E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
  • 組織特異性
    Expressed in both normal and transformed breast epithelial cell lines.
  • 配列類似性
    Contains 2 IBR-type zinc fingers.
    Contains 3 RanBP2-type zinc fingers.
    Contains 1 RING-type zinc finger.
    Contains 1 UBA domain.
  • ドメイン
    The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

参考文献

ab22938 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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