製品の概要

  • 製品名Human RBPJK peptide

製品の詳細

  • 由来Synthetic

特性

Our Abpromise guarantee covers the use of ab26983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 製品の状態Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • AI843960
    • CBF 1
    • CBF-1
    • CBF1
    • IGKJRB1
    • J kappa recombination signal binding protein
    • J kappa-recombination signal-binding protein
    • KBF2
    • NY REN 30 antigen
    • RBP J kappa
    • RBP-J
    • RBP-J kappa
    • RBP-JK
    • Rbpj
    • RBPJK
    • RBPSUH
    • Recombining binding protein suppressor of hairless
    • Renal carcinoma antigen NY-REN-30
    • SUH_HUMAN
    see all
  • 機能Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.
  • 配列類似性Belongs to the Su(H) family.
    Contains 1 IPT/TIG domain.
  • 細胞内局在Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
  • Information by UniProt

Human RBPJK peptide (ab26983) 使用論文

ab26983 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"